Amyotrophic lateral sclerosis (ALS), is a rapidly progressive, invariably fatal neurological disease that attacks the nerve cells (neurons) responsible for controlling voluntary muscles. The disease belongs to a group of disorders known as motor neuron diseases, which are characterized by the gradual degeneration and death of motor neurons.
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Adult Stem Cells Treat Alzheimer's in Animals
Researchers at the Burnett School of Biomedical Sciences at the University of Central Florida today announced positive results in the treatment of Alzheimer's disease with adult stem cells in mice.
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BrainStorm Develops New ALS Therapy
The adult stem cell company BrainStorm Cell Therapeutics announced today that it has entered into an agreement with Protein Production Services, a leading manufacturing contractor, in order to begin production of its therapeutic adult stem cell product for the treatment of ALS (amyotrophic lateral sclerosis, also known as Lou Gehrig's disease). The
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Neuralstem Awarded Adult Stem Cell Patent
The company Neuralstem has announced today that it has been awarded a patent for its latest proprietary technology for an adult stem cell therapy that can be used in the treatment of neurological diseases.
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Adult Stem Cells Approved for ALS Clinical Trial
The U.S. company Neuralstem announced today that it has won approval from the FDA to begin clinical trials for the testing of its adult stem cell therapy as a treatment for ALS (amyotrophic lateral sclerosis), also known as Lou Gehrig's disease.
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Adult Stem Cells Treat Cerebral Palsy
Europe's leading stem cell organization, the XCell-Center of Germany, has released results from a follow-up study in which significant improvement was seen in 67% of 45 cerebral palsy patients who were treated with their own autologous adult stem cells derived from bone marrow.
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Stem cells from umbilical cord used for cerebral palsy treatment
Cerebral palsy is a major health problem, affecting approximately 1 in 500 newborns. It is caused by damage to the brain by lack of oxygen before birth. The scientific rationale for the use of stem cells for this condition has been discussed previously in the video Stem Cell Therapy for Cerebral Palsy.
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Mannitol Boosts Effectiveness of Potential Cord Blood Treatment for CP
The sugar-alcohol compound mannitol improved the therapeutic effectiveness of human umbilical cord blood cells injected into neonatal rat models of cerebral palsy, reports a new international study led by the University of South Florida. The mannitol opened the blood-brain barrier by temporarily shrinking the tight endothelial cells that make up the barrier.
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History of Cerebral Palsy in Children
Cerebral palsy is not a new disorder. There have probably been children with cerebral palsy as long as there have been children. But the medical profession did not begin to study cerebral palsy as a distinct medical condition until 1861.
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New Treatment Helps Control Involuntary Crying and Laughing
Pseudobulbar affect (PBA) is a neurologic condition of involuntary, sudden and frequent episodes of laughing or crying and is quite common in patients with underlying neurologic diseases or injuries, especially those with multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS).
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Individuals With Alzheimer's Disease May Lose Muscle Mass
Lean mass -- the weight of an individual's bones, muscles and organs without body fat -- appears to decline among patients with Alzheimer's disease, according to a report in the April issue of Archives of Neurology, one of the JAMA/Archives journals. These decreases may be associated with declines in brain volume and function.
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New Embryonic Stem Cell Trials Approved to Treat Rare Form of Blindness
In what could be a significant step forward for human embryonic stem cell science Massachusetts based Advanced Cell Technology (ACT) has announced that the FDA have granted orphan drug status to MA09-hRPE ¨C a human embryonic stem cell (hESC) derived treatment for a rare type of blindness known as Stargardt's Macular Dystrophy.
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Cerebral Palsy Statistics
Because cerebral palsy influences the way children develop, it is known as a developmental disability. In the United States today, more people have cerebral palsy than any other developmental disability, including Down syndrome, epilepsy, and autism.
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Therapy and Treatment for Cerebral Palsy
Following your child's interdisciplinary assessment, the professionals providing care for your child will develop recommendations for treatment of his or her cerebral palsy. Many treatments are available to help a child function at the highest level possible. Although many treatments are available, we will touch upon a few of the most basic approaches used today to help a children with cerebral palsy achieve their optimal level of functioning.
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The Cerebral Palsy and the treatment
The term cerebral palsy refers to any one of a number of neurological disorders that appear in infancy or early childhood and permanently affect body movement and muscle coordination but don't worsen over time.
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Major ALS breakthrough-common cause of all forms of ALS discovered
The underlying disease process of amyotrophic lateral sclerosis (ALS and Lou Gehrig's disease), a fatal neurodegenerative disease that paralyzes its victims, has long eluded scientists and prevented development of effective therapies. Scientists weren't even sure all its forms actually converged into a common disease process.
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Cerebral Palsy Diagnosis
How is the diagnosis of cerebral palsy made? When an infant or child has brain damage, a variety of symptoms can lead doctors and parents to suspect that something is wrong. In the first few months of life, an infant with brain damage may demonstrate some or all of the following symptoms that can indicate.
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Turn 'Signals' for Neuron Growth Identified
A new paper scheduled for publication in the January issue of Nature Photonics describes the use of spinning microparticles to direct the growth of nerve fiber, a discovery that could allow for directed growth of neuronal networks on a chip and improve methods for treating spinal or brain injuries.
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New Genetic Mutation for Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia
Unusual repeated segment responsible for more than a third of familial ALS cases worldwide. A team led by scientists from Johns Hopkins and the National Institutes of Health has discovered a new genetic mutation for amyotrophic lateral sclerosis (ALS) and a related disease called frontotemporal dementia (FTD) that appears to account for more than a third of all inherited cases of these diseases. The researchers show in a new study published online on September 21 in Neuron that this mutation, found within a gene called C9ORF72, is about twice as common as all the other mutations discovered thus far for the disease combined.
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Neuron-Damaging Mechanism Discovered in Mouse Model of Inherited ALS
New research uncovers what may be a primary neuron-damaging insult that occurs in an inherited form of a devastating neurodegenerative disorder. The study, published in the August 26th issue of the journal Neuron, describes a critical mechanistic link between a mutant protein and disease pathogenesis in an animal model of amyotrophic lateral sclerosis (ALS).
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Stem Cell Model Offers Clues to Cause of Inherited ALS
An international team of scientists led by researchers at the University of California, San Diego School of Medicine have used induced pluripotent stem cells (iPSCs) derived from patients with amyotrophic lateral sclerosis (ALS) to reveal for the first time how reduced levels of a specific protein may play a central role in causing at least one inherited form of the disease.
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Mild Obesity Appears to Improve Survival in Amyotrophic Lateral Sclerosis Patients
Patients with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, may be an exception to the rule that being overweight is a health hazard. In a retrospective study of over 400 ALS patients, Massachusetts General Hospital (MGH) researchers found that those who were mildly obese survived longer than patients who were normal weight, underweight or even overweight. The study will appear in the journal Muscle & Nerve and has been published online.
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Cause Of Amyotrophic Lateral Sclerosis (ALS)
Two substantial studies, and articles published by The Lancet Neurology have confirmed that variations to the genes located on chromosome number nine may contribute to the development of front temporal dementia and also ALS, amyotrophic lateral sclerosis which is commonly known as Lou Gehrig's Disease. Lou Gehrig, an American baseball player with the New York Yankees, was diagnosed with ALS June 19, 1939 on his 36th birthday and the condition has bared his name ever since.
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New Discovery May Block Amyotrophic Lateral Sclerosis (ALS) Disease Process
In the first animal model of Amyotrophic Lateral Sclerosis (ALS), developed by Dr. Udai Pandey, Assistant Professor of Genetics at LSU Health Sciences Center New Orleans, Dr. Pandey's lab has found in fruit flies that blocking the abnormal movement of a protein made by a mutated gene called FUS also blocks the disease process.
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Loss of Key Protein Boosts Neuron Loss in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis, known as ALS or more popularly, Lou Gehrig's disease, is a notorious neurodegenerative condition characterized by the progressive deterioration of brain and spinal cord neurons, resulting in the gradual but catastrophic loss of muscle control and ultimately, death.
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Decline in Cerebral Palsy Diagnoses in Premature Infants Suggests Improvements in Perinatal Care
Cerebral palsy is a neurodevelopmental condition that affects motor function, more often in children born prematurely. Because cerebral palsy is a result of brain injury received shortly before, during, or soon after birth, the number of infants being diagnosed with the condition is a good indicator of the quality of perinatal and neonatal care. An article soon to be published in the Journal of Pediatrics indicates that the rates of cerebral palsy have declined dramatically in the past 15 years.
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