Parkinson's disease is a degenerative disorder of the central nervous system that often impairs the sufferer's motor skills, speech, and other functions. It belongs to a group of conditions called movement disorders. It is characterized by muscle rigidity, tremor, a slowing of physical movement and, in extreme cases, a loss of physical movement.
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The research into using stem cells to treat Parkinson's disease
Parkinson's disease is a progressive neurodegenerative disorder caused by the loss of dopaminergic neurons in the substantia nigra. This causes a reduction in dopamine secretion. The patient is presented with tremors, stiffening of the four limbs, slow and difficult movements and difficulty with maintaining balance while walking or standing.
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Helping Neurons Fix Themselves In Parkinson's Patients
A Michigan State University researcher is working to uncover how a protein known as parkin may help nerve cells fight off damage from Parkinson's disease, a strategy that could lead to new therapies for the degenerative ailment.
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Industrial Cleaner Linked To Increased Risk Of Parkinson's Disease
Workers exposed to tricholorethylene (TCE), a chemical widely used to clean metal such as auto parts, may be at a significantly higher risk of developing Parkinson's disease, according to a study released today that will be presented at the American Academy of Neurology's 62nd Annual Meeting in Toronto April 10 to April 17, 2010.
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Nerve Cells In Parkinson's Disease Suffer Communication Breakdown
A new study from The Montreal Neurological Institute and Hospital - The Neuro - at McGill University is the first to discover a molecular link between Parkinson's disease and defects in the ability of nerve cells to communicate. The study, published in the prestigious journal Molecular Cell and selected as Editor's Choice in the prominent journal Science, provides new insight into the mechanisms underlying Parkinson's disease, and could lead to innovative new therapeutic strategies.
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An Ibuprofen a Day Could Keep Parkinson's Disease Away
New research shows people who regularly take ibuprofen may reduce their risk of developing Parkinson's disease, according to a study released February 17 that will be presented at the American Academy of Neurology's 62nd Annual Meeting in Toronto April 10 to April 17, 2010.
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Early Steps in Parkinson's Pathology Revealed
Although the cause of Parkinson's disease remains a mystery, scientists now have a better understanding of the earliest stages of abnormal aggregation of a key disease-associated protein. The research, published online on April 6th in Biophysical Journal, provides new insight into the first steps in the formation of neurotoxic structures called Lewy bodies that are the hallmark of the Parkinson's brain.
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[News]
Early Steps in Parkinson's Pathology Revealed
Although the cause of Parkinson's disease remains a mystery, scientists now have a better understanding of the earliest stages of abnormal aggregation of a key disease-associated protein. The research, published online on April 6th in Biophysical Journal, provides new insight into the first steps in the formation of neurotoxic structures called Lewy bodies that are the hallmark of the Parkinson's brain.
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[News]
'Mouse Models' Give Insight to Gene Mutation Potential Cause of Parkinson
Using new one-of-a-kind "mouse models" that promise to have a significant impact on future Parkinson's disease research, Mount Sinai School of Medicine researchers are among the first to discover how mutations in a gene called LRRK2 may cause inherited (or "familial") Parkinson's disease, the most common form of the disease.
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Parkinson's Disease Treatments Associated With Compulsive Behaviors
These behaviors have been reported previously in patients with Parkinson's disease, according to background information in the article. Preliminary estimates of impulse control disorders in this population range from 1.7 percent to 6.1 percent for gambling, 2 percent to 4 percent for compulsive sexual behavior and 0.4 percent to 3 percent for compulsive buying.
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Parkinson's: New Clues to Alleviating Gait Disorders and Falls
Many of the symptoms of Parkinson disease can be alleviated with drugs that target dompamine, a chemical in the brain that is involved in nerve cell communication and therefore known as a neurotransmitter. However, such drugs do not improve the gait disorders and falls that commonly affect individuals with severe and advanced forms of Parkinson disease.
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Deep Brain Stimulation Similar Motor Benefits in Parkinson's
In a major study, investigators have compared how individuals with Parkinson's disease respond to deep brain stimulation (DBS) at two different sites in the brain. Contrary to current belief, patients who received DBS at either site in the brain experienced comparable benefits for the motor symptoms of Parkinson's.
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New Findings on Troubling Side Effects of Parkinson¡¯s Medication
One in every 100 elderly people suffers from Parkinson's disease, a disease of the nervous system with symptoms including stiffness and shaking. The standard medication used to treat Parkinson's is Levodopa, a drug that initially has major benefits but can later also produce serious side effects in the form of involuntary, jerky movements.
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[News]
Early Steps in Parkinson's Pathology Revealed
Although the cause of Parkinson's disease remains a mystery, scientists now have a better understanding of the earliest stages of abnormal aggregation of a key disease-associated protein. The research, published online on April 6th in Biophysical Journal, provides new insight into the first steps in the formation of neurotoxic structures called Lewy bodies that are the hallmark of the Parkinson's brain.
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[News]
What Happens to Nerve Cells in Parkinson's Disease
A new study from The Montreal Neurological Institute and Hospital -- The Neuro -- at McGill University is the first to discover a molecular link between Parkinson's disease and defects in the ability of nerve cells to communicate. The study, published in the journal Molecular Cell and selected as Editor's Choice in the journal Science, provides new insight into the mechanisms underlying Parkinson's disease, and could lead to innovative new therapeutic strategies.
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[News]
New Findings Shed Light on Parkinson's Disease
It has long been known that "Lewy bodies", one of the hallmarks of Parkinson's disease and related types of neurodegenerative conditions, are formed from the aggregate accumulation of the synaptic protein alpha-synuclein. It has also been understood that the progression of such diseases is associated with the spreading of the Lewy bodies, which continue to infiltrate more and more regions of the brain. It has not previously been understood, however, exactly how the Lewy bodies are able to spread. Now, researchers are one step closer to a full elucidation of the underlying cellular and molecular mechanisms by which Lewy bodies ultimately invade the entire brain.
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Adult Stem Cells Treat Parkinson's
At Jaslok Hospital in Mumbai, 55-year-old Bhawarlal Jain has received autologous adult stem cell therapy for the treatment of Parkinson's disease. Mr. Jain has suffered from advanced symptoms of the disease for 6 years, which included spondylitis - inflammation of the vertebrae - and other joint pain since 2004. According to Jain, "I managed my business until my speech became so impaired that I had to repeat everything at least four times to be understood."
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