http://www.stemcellresearchnews.com/absolutenm/anmviewer.asp?a=2002&z=9
Monday, February 15, 2010 - Stem Cell Research News
A new study comparing the ability of induced pluripotent stem (iPS) cells and embryonic cells to transform into brain cells has found that induced cells ¨C even those free of the genetic factors used to program their all-purpose qualities ¨C differentiate less efficiently and faithfully than their embryonic counterparts.
The finding casts doubt on the belief that the all-purpose cells are fully capable of functioning the same as embryonic stem cells, but without the controversy.
That induced cells are less predictable means there are more kinks to work out before they can be used reliably in a clinical setting, said Su-Chun Zhang, the senior author and a professor in the University of Wisconsin-Madison School of Medicine and Public Health.
"Embryonic stem cells can pretty much be predicted," Zhang said. "Induced cells cannot. That means that at this point there is still some work to be done to generate ideal induced pluripotent stem cells for application."
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