Before treatment:
Elizabeth started having abnormal movements in the tongue muscles about 5 months ago, and would often bite the tongue on the left side first and then bite the right side. At this time there were no other symptoms. She went to the dental department for treatment at a local hospital, and it was suspected that abnormalities of her teeth were the cause. After corrections were made to her teeth, there was no obvious improvement. About four months ago, Elizabeth started suffering from pain in both feet and upper limbs. The cause of this pain was not clear. The pain in the left hand was the most severe, and she had limited use of the hand. Her family doctor gave her an examination and referred her to the neurology department. She developed barylalia about three months ago, had excessive salivation from the left side of her mouth, and a burning sensation on her skin. Elizabeth has had muscular fibrillation in both upper limbs for about two months and developed muscular fibrillation in both lower limbs about one month ago. She also has shortness of breath. Soon after these additional symptoms occurred, Elizabeth received an MRI and EMG and was diagnosed with ALS on June 24. Her local hospital administered treatment but there were no obvious improvements to her condition.

Elizabeth had heard about our medical center's unique treatment for ALS. The doctors here have the ability to slow down the progress of the disease and improve the overall condition of patients with ALS. Because of this, Elizabeth made the decision to come to our medical center for treatment.

Nervous System Examination:

Elizabeth was alert and her mental faculties were good. Her memory, calculation abilities and orientation were normal. Both pupils were equal in size, the diameter was 3mm. Both eyeballs could move flexibly and the pupils reacted normally to light stimulus. The forehead wrinkle pattern and nasolabial sulcus was symmetrical. Elizabeth had strong eye closing ability. The tongue was centered in the middle of the oral cavity and the teeth were shown without deflection. The fibrillation in the lingualis and the resulting indentation was visible. The indentation on the left side of the tongue was more obvious. There was atrophy in the tongue muscles, but there was flexibility. The bilateral soft palate rose symmetrically. The neck is soft and the head can turn normally. The shrugging strength of the shoulders was weak, the muscle volume of the proximal ends of both upper limbs were decreased. The muscle strength of the right upper limb was level 5-, the muscle strength of the other limbs was level 5, the muscle tone of all four limbs was normal, the tendon reflexes were active, the abdominal reflex was not elicited. The bilateral palmomental reflex was negative, the sucking reflex was negative, the bilateral Hoffmann's sign was positive, the bilateral Rossilimo's sign was positive, the counterattack of left side was negative, the counterattack of right side was weak positive. The left side Babinski's sign was negative; the right side Babinski's sign was weak positive. Elizabeth had normal sensation and epicritic sensation. She was able to finish the finger-to-nose test in a stable manner. The left side was unable to complete the rapid rotation test and digital opposition test normally. And her right side was uncoordinated with the rapid rotation test and digital opposition test. The heel-knee-shin test of both legs was stable. There were no signs of meningeal irritation.